Association of rs9939609 polymorphism in the FTO gene with features of androgen status in men

The purpose of the study was to investigate association carriage rs9939609 polymorphism in FTO gene with features androgen status men. Material and methods. observational one-stage examination 139 male patients aged 22 69 years, admitted a therapeutic hospital planned manner has been carried out Clinic Federal Research Center for Fundamental Translational Medicine period 2020–2021. All fasting men morning (8:00–8:30) were an anthropometric determine physical development, sampling venous blood from cubital vein assess hormonal parameters status, taking sample buccal epithelium molecular genetic research. Based on (T>A) gene, following groups (G) distinguished: G1 – wild-type homozygotes (WT/WT), G2 heterozygotes (WT/A), G3 mutant allele (A/A). Results discussion. statistically significant differences found levels total testosterone between (11.6 vs 14.5 nmol/L, p = 0.010), as well free compared (0.233 0.287 0.012) 0.321 0.002) when analyzing clinical-anthropometric examined selected groups. Assessment revealed positive correlations ( r 0.247; 0.013) 0.296; 0.003) testosterone, negative - frequency deficiency according criteria –0.240; 0.016). Conclusions. It shown that A/A genotype is associated increase indicates protective effect against development obtained results suggest this due epigenetic protein product expression other genes involved synthesis androgens gonads, but also adrenal cortex since no DHEA-C level found.